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Designed for use with tablet presses, Syntegon’s automatic powder feeder and APD software offer a complete package for pharmaceutical manufacturers to define ideal process parameters for each product and easily transfer them to production machines.
“While manual analyzes take days or weeks, the APD tool achieves faster and more accurate results with less product,” says Matthias Moessinger, senior market expert for Pharma Solid at Syntegon. “Tablets have many more relevant parameters and quality attributes compared to capsules – from shape or diameter to thickness and hardness, many properties play an important role.”
The new powder feeding system is specially adapted TPR 200 Tablet press from Syntegon. The system can be automatically adjusted to suit every possible mixer configuration. The wheels have a square and round side to reflect factors such as the effect of powder movement on tablet properties. In addition, the speed and direction of rotation, as well as the inclination of the mixing blades, can be different.
During product testing, APD software evaluates and optimizes process parameters for their impact on critical quality attributes. As a key feature, both feed system replacement and testing are fully automated; human intervention is no longer necessary. The APD tool is based on Design of Experiments (DoE) and analyzes the functional relationships between material properties, process parameters and critical quality characteristics of the final product. This allows pharmaceutical manufacturers to accurately simulate production situations and determine reliable parameters thanks to a well-defined database. They save time, reduce product loss, increase product quality, and facilitate process control.
The APD tool is suitable for tests in the development phase as well as for optimizing existing processes. Together with customers, Syntegon tests both active ingredients and placebo formulations at the OSD Customer Center in Weiblingen with an automated feeding system. “Our experts know the challenges and can support pharmaceutical manufacturers in determining the optimal process parameters based on decades of experience,” says Moessinger. “We have been a leader in capsule processing technology for many years. Now our APD tool and automated powder feeding system offer customers a structured and highly efficient solution for process optimization in tablet pressing. There will be further innovations.”
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